Matrixyl – What does it do? How do peptides work on the skin?

Author: Mike Clague   Date Posted:3 August 2017 

Matrixyl 3000 is a collagen stimulating peptide. There are different types of this peptide. We use Matrixyl 3000 in our skin care.

As the name suggests, collagen-stimulating peptides are short chains of amino acids that stimulate the skin to make collagen. Perhaps the most well known peptides in this group are Matrixyl® 3000 and SYN®-Coll.

There are various types of Matrixyl, but the primary active ingredient is a peptide with ve amino acids KTTKS (lysine–threonine–threonine– lysine–serine). With 5 amino acids these types of peptides are called ‘pentapeptides’.

Other collagen-stimulating peptides that you can look for on the label include Biopeptide-CL (Pal-GHK), Tripeptide-10 Citrulline (DecorinylTM), Acetyl tetrapeptide-9 (AcTP1), Acetyl tetrapeptide-11 (AcTP2), and Peptamide-6. Since these peptides are applied topically, they must penetrate the outer layers of skin and reach the deepest layers in order to bring about their effectxxiii. To help these peptides get through to the deeper layers they often add a fatty acid ‘carrier’ like palmitic acid.

Matrixyl® has been scientifically studied more extensively than other collagen-stimulating peptides. Matrixyl® stimulates the skin to produce various types of collagen and elastin.

One study in human subjects where patients used 3% Matrixyl® vs placebo in a half face treatment for 6 months showed significant decreases in wrinkle depth (-21.6%), roughness of the skin (-16.4%), wrinkle volume (-24%) and main wrinkle density (-46.8%)xxv.

A study by Dr. Lijuan Zhang and Dr. Timothy Falla on peptides states that Matrixyl 3000 has beneficial effects on the skin as it reduces inflammation and promotes integrity of the dermal layers. There have been many studies discussing the affect of Matrixyl on collagen fibres.

Dr Catherine Huang from the David Geffen School of Medicine states “There appears to be an overwhelming body of evidence that pal-KTTS (Matrixl®) is effective in decreasing facial wrinkles and roughness.

Speaking from personal experience with my own patients I know that I have seen great results with Matrixyl® in terms of wrinkle reduction and smoothing of the skin. Remember you need concentrations around 5% to get an outcome and the raw ingredients are expensive, so if the price is too low then it’s unlikely that you will achieve optimal results.

References available at

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