Smoother skin with Retinol – evidence based skin care

Author: Mike Clague   Date Posted:29 September 2017 

Clinical evidence for the use of Retinol in skin care


Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety

Clin Interv Aging. 2006 Dec; 1(4): 327–348.

Retinol has been proven to improve wrinkles, smooth the skin, enhance collagen synthesis, smooth out pigmentation and create other skin benefits. Retinol belongs to the family of endogenous natural retinoids and is a precursor for synthesis of endogenous retinal and retinoic acid.

In 2007 Kafi et al conducted a study in which 36 elderly patients (mean 86 years old) had either 0.4% Retinol (in a moisturizer) or just the moisturizer applied to their left or right arm 3 times a week for 24 weeks. Using just a moisturizer provided a ‘control’ in other words an untreated area of the study so that their could be accurate measurement of the retinol effects. Measurements were conducted by taking a biopsy of the patients skin of the arm.

The researchers found that topical retinol improves fine wrinkles associated with natural aging. Significant induction of glycosaminoglycan, which is known to retain substantial water, and increased collagen production are most likely responsible for wrinkle reduction. With greater skin matrix synthesis, retinol-treated aged skin is more likely to withstand skin injury and ulcer formation along with improved skin appearance. Arch Dermatol. 2007;143(5):606-612. doi:10.1001/archderm.143.5.606

Although retinol has been used in over the counter cosmetic products since 1984 (Rolewski 2003), its potential in the treatment of sun damage was realized when Kang et al (1995) showed that application of all-trans-retinol on normal human skin encourages epidermal thickening (the epidermis is the outer skin layer) and enhances the expression of certain messenger RNA’sm and proteins, as does prescription strength retinoic acid. Moreover, the authors also observed that retinol showed only minimal signs of redness and irritation unlike prescription strength retinoic acid.

Interestingly, Fisher and colleagues (1996, 1997) also demonstrated that retinol stimulates collagen synthesis in photoaged skin.

Pierard-Franchimont and colleagues (1998) first conducted a controlled clinical trial with retinol formulation. They observed that retinol formulation resulted in significant improvement in fine wrinkles after 12 weeks of treatment.

Fibroblast cells produce collagen. Retinol has been shown to increase fibroblast growth and enhance collagen production. Varani and colleagues (2000) studied the effect of topical application of 1% retinol in 53 individuals (80 years or above) with aged skin. The authors observed that retinol application for 7 days reduced MMP (matrix metalloproteinase), collagenase (breaks down collagen), and gelatinise expression. They also found an increase in fibroblast growth and collagen synthesis in the studied tissue specimens. Thus, it can be concluded that retinol should be effective in the treatment of aging and photoaging.

Why should you choose our Retinol skin care?

Retinol has many benefits for the skin. You need to make sure the concentration is close to 1% for the best results. Our Reactivate Collagen Stimulator contains 0.9% retinol plus Matrixl Peptide. Matrixl peptide adds benefits of collagen stimulation and wrinkle reduction to our serum. It is an ideal ONE, TWO punch in the smoothing of wrinkles and anti-aging.

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